The RNA modification N6-methyladenosine (m6A) plays a critical role in post-transcriptional control of gene expression. Our research has demonstrated that m6A regulates viruses in the Flaviviridae family, including dengue, Zika, West Nile, and hepatitis C viruses, through multiple mechanisms by acting on both viral and cellular RNA substrates. We have found that these viruses reprogram m6A modification patterns on both host and viral RNA, leading to changes in RNA metabolism that impact infection outcomes. This talk will present our latest understanding of how m6A is regulated during viral infection. It will focus on mechanisms by which viruses exploit and are regulated by the m6A machinery, including altered targeting of methyltransferase complexes to specific transcripts and the discovery of novel m6A reader proteins that regulate viral infection. Overall, our work reveals novel RNA-mediated regulatory mechanisms that are altered during viral infection and provides new insights into mechanisms that can broadly regulate m6A deposition and function.