Long non-coding RNAs (lncRNAs) are defined as transcripts longer than 500 nucleotides which do not encode open reading frames for translation into proteins. Transcriptomic studies have recorded over 100,000 lncRNAs, yet only a fraction of these have been functionally characterised. Epithelial-mesenchymal transition (EMT) is a reversible process by which cells shift between epithelial and mesenchymal phenotypes in response to signals from the microenvironment and acquire traits including enhanced motility and invasiveness. The process plays a crucial role in development, wound healing, cancer progression and metastasis. EMT is now understood as a reversible epigenetic regulatory program that involves extensive changes throughout the transcriptome, including non-coding RNAs. In this project, we have re-mapped our bulk sequencing data from a human mammary cell-derived EMT model (Human mammary epithelial cell, HMLE), comparing gene expression in epithelial (HMLE) and mesenchymal (mesHMLE) states. From this, we have identified five lncRNAs that are relatively high in expression in epithelial cells but show minimal expression in mesenchymal cells. We have investigated their responsiveness to pro-mesenchymal (TGF-B) and pro-epithelial (miR-200c) stimuli and perturbed their expression, resulting in changes in the expression of epithelial genes including E-cadherin, and effects on cell phenotype as indicated via various cell biology assays .